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Chemical Structure : CC-885
CAS No.: 1010100-07-8
Catalog No.: PC-60125Not For Human Use, Lab Use Only.
CC-885 (CC 885, CC885) is a novel E3 ligase cereblon (CRBN) modulator with potent anti-tumour activity mediated through the degradation of GSPT1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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CC-885 (CC 885, CC885) is a novel E3 ligase cereblon (CRBN) modulator with potent anti-tumour activity mediated through the degradation of GSPT1.
The anti-tumour activity of CC-885 is mediated through the cereblon-dependent ubiquitination and degradation of the translation termination factor GSPT1.
CC-885 promotes both the in vivo and in vitro ubiquitination of GSPT1 by cereblon and decreases the protein half-life of GSPT1.
| M.Wt | 440.9 | |
| Formula | C22H21ClN4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 100 mM (44 mg/mL). |
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| Chemical Name/SMILES |
N-(3-chloro-4-methylphenyl)-N'-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-urea |
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1. Collins I, et al. Biochem J. 2017 Mar 15;474(7):1127-1147.
2. Matyskiela ME, et al. Nature. 2016 Jul 14;535(7611):252-7.
3. Hansen JD, et al. J Med Chem. 2017 Apr 13. doi: 10.1021/acs.jmedchem.6b01911.
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