CC-8977 (CaMKK2-IN-1) | CaMKK2 inhibitor

Chemical Structure : CC-8977

CAS No.: 3032691-65-6

CC-8977 (CC8977, CaMKK2-IN-1)

Catalog No.: PC-21443Not For Human Use, Lab Use Only.

CC-8977 (CaMKK2-IN-1) is a hgihly potent, selective inhibitor of calcium/calmodulin-dependent kinase kinase II (CaMKK2) with binding IC50 of 7 nM.

Packing	Price	Stock
2 mg	$188	In stock
5 mg	$298	In stock
10 mg	$488	In stock
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Biological Activity

CC-8977 (CaMKK2-IN-1) is a hgihly potent, selective inhibitor of calcium/calmodulin-dependent kinase kinase II (CaMKK2) with binding IC50 of 7 nM.
CC-8977 inhibits phosphorylation of AMPK in LKB1 null A427 cells with IC50 of 170 nM.
CC-8977 shows CaMKK1 binding IC50 of 26 nM.
CC-8977 displays high selectivity against a panel of 259 kinases.

Physicochemical Properties

M.Wt	362.43
Formula	C22H22N2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-cyclopentyl-4-(7-ethoxyquinazolin-4-yl)benzoic acid

References

1. Chen Y, et al. J Med Chem. 2023 Dec 14;66(23):15750-15760.

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CC-8977 (CC8977, CaMKK2-IN-1)

Biological Activity

Physicochemical Properties

References

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