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CC-8977

Chemical Structure : CC-8977

CAS No.: 3032691-65-6

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CC-8977 (CC8977)

Catalog No.: PC-21443Not For Human Use, Lab Use Only.

CC-8977 is a hgihly potent, selective inhibitor of calcium/calmodulin-dependent kinase kinase II (CaMKK2) with binding IC50 of 7 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CC-8977 is a hgihly potent, selective inhibitor of calcium/calmodulin-dependent kinase kinase II (CaMKK2) with binding IC50 of 7 nM.
    CC-8977 inhibits phosphorylation of AMPK in LKB1 null A427 cells with IC50 of 170 nM.
    CC-8977 shows CaMKK1 binding IC50 of 26 nM.
    CC-8977 displays high selectivity against a panel of 259 kinases.

    Physicochemical Properties

    M.Wt 362.43
    Formula C22H22N2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-cyclopentyl-4-(7-ethoxyquinazolin-4-yl)benzoic acid

    References

    1. Chen Y, et al. J Med Chem. 2023 Dec 14;66(23):15750-15760.

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