Catalog No.: PC-21906Not For Human Use, Lab Use Only.
CC-99677 (Gamcemetinib, BMS-986371) is a potent, selective, covalent and orally bioavailable MAPKAPK2 (MK2) inhibitor with IC50 of 156.3 nM, potently inhibits HSP27 phosphorylation (pHSP27) with EC50 of 89 nM.
CC-99677 (Gamcemetinib, BMS-986371) is a potent, selective, covalent and orally bioavailable MAPKAPK2 (MK2) inhibitor with IC50 of 156.3 nM, potently inhibits HSP27 phosphorylation (pHSP27) with EC50 of 89 nM.
CC-99677 covalently binds MK2 with Ki of 171.7 nM.
CC-99677 potently inhibits TNFα and GM-CSF (IC50=67 nM, 258 nM, respectively) and moderately inhibits IL-6 (IC50=865 nM) in LPS-stimulated PBMCs.
CC-99677 (20 & 100 mg/kg CC-99677 PO) inhibits paw swelling in a rat model of ankylosing spondylitis (AS), shows favorable safety in healthy human subjects in clinical investigations.
