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CC15009

Chemical Structure : CC15009

CAS No.: 2482713-67-5

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CC15009 (CC-15009)

Catalog No.: PC-22859Not For Human Use, Lab Use Only.

CC15009 is a potent, specific xanthine oxidoreductase (XOR) inhibitor, inhibits XOR-catalyzed uric acid synthesis in vitro with IC50 of 0.237 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CC15009 is a potent, specific xanthine oxidoreductase (XOR) inhibitor, inhibits XOR-catalyzed uric acid synthesis in vitro with IC50 of 0.237 nM.
CC15009 significantly inhibited liver XOR activity with IC50 of 1.07 nM, inhibits liver xanthine oxidase (XO) and NAD+-dependent xanthine dehydrogenase (XDH) with IC50 of 1.9 nM and 1.06 nM respectively.
CC15009 1 mg/kg shows uric acid-lowering effect in XOR substrate-induced mouse models.

Physicochemical Properties

M.Wt 434.32
Formula C20H21Cl2N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(3-(2,6-dichloro-4-(5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl)phenoxy)propyl)morpholine

References

1. Xuechen Li, et al. Biomed Pharmacother. 2024 Aug 1:178:117223.

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