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Chemical Structure : CCB02
CAS No.: 2100864-57-9
Catalog No.: PC-35881Not For Human Use, Lab Use Only.
CCB02 (CCB 02) is a specific small molecule inhibitor of CPAP-tubulin interaction with IC50 of 0.689 uM in AlphaScreen assay, selectively binds at the CPAP binding site of tubulin.
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| 5 mg | $248 | In stock | |
| 10 mg | $388 | In stock | |
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CCB02 (CCB 02) is a specific small molecule inhibitor of CPAP-tubulin interaction with IC50 of 0.689 uM in AlphaScreen assay, selectively binds at the CPAP binding site of tubulin.
CCB02 does not inhibits a panel of cell cycle- and centrosome-related kinases.
CCB02 impairs proliferation of cells with centrosome amplification, activates extra centrosomes to nucleate enhanced numbers of microtubules prior to mitosis, causes cells to undergo centrosome de-clustering, prolonged multipolar mitosis, and cell death.
CCB02 demonstrates broad anti-invasive activity in various cancer models, including tyrosine kinase inhibitor (TKI)-resistant EGFR-mutant NSCLC.
| M.Wt | 235.246 | |
| Formula | C14H9N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-methoxybenzo[b][1,6]naphthyridine-4-carbonitrile |
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1. Mariappan A, et al. EMBO J. 2018 Dec 10. pii: e99876. doi: 10.15252/embj.201899876.
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