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Chemical Structure : CCC07-01
Catalog No.: PC-35252Not For Human Use, Lab Use Only.
CCC07-01 (CCC 0701) is a novel alkylating compound that is capable of disrupting expression of PD-1, PD-L1 and CTLA-4 genes with IC50 of 15, 10 and 5 nM in cell-base assays.
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CCC07-01 (CCC 0701) is a novel alkylating compound that is capable of disrupting expression of PD-1, PD-L1 and CTLA-4 genes with IC50 of 15, 10 and 5 nM in cell-base assays; significantly suppresses PD-1, PD-L1 and CTLA-4 mRNA levels in several cell lines, CCC07-01 is sufficiently lipophilic that enhaced the inhibitory effect of CD94-NKG-2A receptor expressed on subsets of NK cells γδ and CD8+ T cells.
| M.Wt | 1886.378 | |
| Formula | C90H93ClN30O16 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. US Patent WO 2018056361.
2. Horiki Nagase, et al. 2018 AACR #2711: Development of a new innovative multifunctional immune checkpoint inhibitor.
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