Chemical Structure : CCF219B
CAS No.:
2521695-94-1
CCF219B
(Compound 3, Cmpd-3)
Catalog No.: PC-24568Not For Human Use, Lab Use Only.
CCF219B (Compound 3, Cmpd-3) is a potent, selective positive allosteric modulator of the α1A-adrenergic receptor (α1A-AR) with an affinity of 30 nM, 10-50-fold selectivity against the α1B- and α1D-AR subtypes.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CCF219B (Compound 3, Cmpd-3) is a potent, selective positive allosteric modulator of the α1A-adrenergic receptor (α1A-AR) with an affinity of 30 nM, 10-50-fold selectivity against the α1B- and α1D-AR subtypes.
Cmpd-3 PAM activity is receptor, ligand, and signal-biased; potentiation of NE-mediated but not Epi-mediated cAMP.
Cmpd-3 is not an agonist and is a pure PAM.
Cmpd-3 potentiates the phosphorylation of p-CREB, Cmpd-3 increases NE-mediated phosphorylation of CREB in the presence of α2-and β-AR blockers.
Cmpd-3 can potentiate the NE-mediated cAMP response in transfected Rat-1 fibroblasts.
Physicochemical Properties
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M.Wt
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339.45
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Formula
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C16H25N3O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(3-((4,5-dihydro-1H-imidazol-2-yl)methoxy)-2-isobutylphenyl)-N-methylmethanesulfonamide
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References
1. Robert S Papay, et al. Curr Res Pharmacol Drug Discov. 2022 Dec 2:4:100142.
2. Robert S Papay, et al. Pharmaceuticals (Basel). 2025 Mar 27;18(4):476.
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