CCG-17444 | Shroom3-Rock interaction inhibitor

Chemical Structure : CCG-17444

CCG-17444 (CCG17444)

Catalog No.: PC-28451Not For Human Use, Lab Use Only.

CCG-17444 is a small molecule irreversible inhibitor of Shroom3-Rho kinase (ROCK) protein-protein interaction with IC50 opf 12.4 uM, enhances neurite outgrowth in neurons, overcomes growth mediated inhibition by Nogo66.

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Biological Activity

CCG-17444 is a small molecule irreversible inhibitor of Shroom3-Rho kinase (ROCK) protein-protein interaction with IC50 opf 12.4 uM, enhances neurite outgrowth in neurons, overcomes growth mediated inhibition by Nogo66.

Physicochemical Properties

M.Wt	359.46
Formula	C17H17N3O2S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	8,8-dimethyl-5-(thiophen-2-yl)-2-thioxo-2,3,5,8,9,10-hexahydropyrimido[4,5-b]quinoline-4,6(1H,7H)-dione

References

1. Dickson HM, et al. BMC Neurosci. 2015 Jun 16;16:34.

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CCG-17444 (CCG17444)

Biological Activity

Physicochemical Properties

References

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