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CCG-224406

Chemical Structure : CCG-224406

CAS No.: 1870843-22-3

CCG-224406 (CCG 224406;CCG224406)

Catalog No.: PC-70119Not For Human Use, Lab Use Only.

CCG-224406 (CCG224406) is a highly selective and potent GRK2 (G protein-coupled receptor kinase 2) inhibitor with IC50 of 130 nM.M.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CCG-224406 (CCG224406) is a highly selective and potent GRK2 (G protein-coupled receptor kinase 2) inhibitor with IC50 of 130 nM.
    CCG-224406 displays >700-fold selectivity over other GRK subfamilies, and no detectable inhibition of ROCK1.

    Physicochemical Properties

    M.Wt 558.57
    Formula C29H27FN6O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    4-(3-((2,6-dimethoxybenzyl)carbamoyl)-4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

    References

    1. Waldschmidt HV, et al. J Med Chem. 2016 Apr 28;59(8):3793-807.

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