Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : CCG-4986
Catalog No.: PC-60210Not For Human Use, Lab Use Only.
CCG-4986 is a on-peptide, selective RGS4 inhibitor that inhibits RGS4/Gα(o) binding with 3 to 5 uM potency.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
CCG-4986 is a on-peptide, selective RGS4 inhibitor that inhibits RGS4/Gα(o) binding with 3 to 5 uM potency.
CCG-4986 shows selectivity for RGS4 and does not inhibit RGS8.
CCG-4986 binds to RGS4, inhibits RGS4 stimulation of Galpha(o) GTPase activity in vitro, and prevents RGS4 regulation of mu-opioid-inhibited adenylyl cyclase activity in permeabilized cells.
| M.Wt | 374.81 | |
| Formula | C13H11ClN2O5S2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Roman DL, et al. Mol Pharmacol. 2007 Jan;71(1):169-75.
2. Roman DL, et al. Mol Pharmacol. 2010 Sep;78(3):360-5.
3. Cheng YC, et al. Cell Mol Life Sci. 2013 Mar;70(5):935-50.
4. Chen Y, J Neurosci. 2012 Feb 22;32(8):2683-95.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
