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CCG215022

Chemical Structure : CCG215022

CAS No.: 1813527-81-9

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CCG215022 (CCG-215022, CCG 215022)

Catalog No.: PC-45591Not For Human Use, Lab Use Only.

CCG-215022 (CCG215022) is a potent and selective pan GRK (G protein-coupled receptor kinase) inhibitor with IC50 of 0.15/0.38/3.9 uM for GRK2/5/1 respectively.

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5 mg $218 In stock
10 mg $358 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CCG215022 (CCG-215022) is a potent and selective pan GRK (G protein-coupled receptor kinase) inhibitor with IC50 of 0.15/0.38/3.9 uM for GRK2/5/1 respectively.
CCG215022 displays 300-800 fold selectivity against PKA.
CCG215022 exhibits improved potency compared with GSK180736A.

Physicochemical Properties

M.Wt 499.4964
Formula C26H22FN7O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 28 mg/mL
Chemical Name/SMILES

4-(4-fluoro-3-((pyridin-2-ylmethyl)carbamoyl)phenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

References

1. Homan KT, et al. J Biol Chem. 2015 Aug 21;290(34):20649-59.

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