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Chemical Structure : CCT077791
Catalog No.: PC-72239Not For Human Use, Lab Use Only.
CCT077791 (CCT077791) is a small molecule inhibitor of PCAF and p300 histone acetyltransferase with IC50 of 2.2 uM and IC95 of 35 uM, respectively.
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CCT077791 (CCT077791) is a small molecule inhibitor of PCAF and p300 histone acetyltransferase with IC50 of 2.2 uM and IC95 of 35 uM, respectively.
CCT077791 inhibited the growth of a panel of human tumor cell lines (HCT116 GI50=3.0 uM, HT29 GI50=2.1 uM), decreased cellular acetylation in a time- and concentration- dependent manner in HCT116 and HT29 human colon tumor cell lines.
CCT077791 reduced total acetylation of histones H3 and H4, levels of specific acetylated lysine marks, and acetylation of alpha-tubulin.
| M.Wt | 256.66 | |
| Formula | C9H5ClN2O3S | |
| Appearance | Solid | |
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1. Lindsay Stimson, et al. Mol Cancer Ther. 2005 Oct;4(10):1521-32.
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