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CCT077791

Chemical Structure : CCT077791

CAS No.: 748777-47-1

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CCT077791 (CCT 077791)

Catalog No.: PC-72239Not For Human Use, Lab Use Only.

CCT077791 (CCT077791) is a small molecule inhibitor of PCAF and p300 histone acetyltransferase with IC50 of 2.2 uM and IC95 of 35 uM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CCT077791 (CCT077791) is a small molecule inhibitor of PCAF and p300 histone acetyltransferase with IC50 of 2.2 uM and IC95 of 35 uM, respectively.
    CCT077791 inhibited the growth of a panel of human tumor cell lines (HCT116 GI50=3.0 uM, HT29 GI50=2.1 uM), decreased cellular acetylation in a time- and concentration- dependent manner in HCT116 and HT29 human colon tumor cell lines.
    CCT077791 reduced total acetylation of histones H3 and H4, levels of specific acetylated lysine marks, and acetylation of alpha-tubulin.

    Physicochemical Properties

    M.Wt 256.66
    Formula C9H5ClN2O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-Chloro-2-(4-nitrophenyl)-3(2H)-isothiazolone

    References

    1. Lindsay Stimson, et al. Mol Cancer Ther. 2005 Oct;4(10):1521-32.

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