Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : CCT077791
Catalog No.: PC-72239Not For Human Use, Lab Use Only.
CCT077791 (CCT077791) is a small molecule inhibitor of PCAF and p300 histone acetyltransferase with IC50 of 2.2 uM and IC95 of 35 uM, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
CCT077791 (CCT077791) is a small molecule inhibitor of PCAF and p300 histone acetyltransferase with IC50 of 2.2 uM and IC95 of 35 uM, respectively.
CCT077791 inhibited the growth of a panel of human tumor cell lines (HCT116 GI50=3.0 uM, HT29 GI50=2.1 uM), decreased cellular acetylation in a time- and concentration- dependent manner in HCT116 and HT29 human colon tumor cell lines.
CCT077791 reduced total acetylation of histones H3 and H4, levels of specific acetylated lysine marks, and acetylation of alpha-tubulin.
| M.Wt | 256.66 | |
| Formula | C9H5ClN2O3S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Lindsay Stimson, et al. Mol Cancer Ther. 2005 Oct;4(10):1521-32.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
