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CCT369260

Chemical Structure : CCT369260

CAS No.: 2253878-44-1

CCT369260 (CCT 369260)

Catalog No.: PC-38808Not For Human Use, Lab Use Only.

CCT369260 is a highly potent, orally active BCL6 degrader with DC50 of 54 nM in cellular BCL6 degradation assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CCT369260 is a highly potent, orally active BCL6 degrader with DC50 of 54 nM in cellular BCL6 degradation assays.
CCT369260 exhibits an IC50 of 523 nM in BCL6 TR-FRET assays.
CCT369260 showed robust antiproliferative activity in SU-DHL-4 cells, with no antiproliferative activty in a panel of BCL6-negative cell lines.
CCT369260 (50 mg/kg) reduces BCL6 levels in a lymphoma xenograft mouse model following oral dosing.

Physicochemical Properties

M.Wt 508.999
Formula C24H31ClF2N6O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-((5-chloro-2-((3R,5S)-4,4-difluoro-3,5-dimethylpiperidin-1-yl)pyrimidin-4-yl)amino)-3-(3-hydroxy-3-methylbutyl)-1-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one

References

1. Bellenie BR, et al. J Med Chem. 2020 Apr 23;63(8):4047-4068.

2. Rosemary Huckvale, et al. J Med Chem. 2022 Jun 2. doi: 10.1021/acs.jmedchem.1c02175.

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