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CCT369347

Chemical Structure : CCT369347

CAS No.: 2253786-82-0

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CCT369347 (CCT-369347)

Catalog No.: PC-72519Not For Human Use, Lab Use Only.

CCT369347 (CCT-369347) is potent selective inhibitor of BCL-6 with TR-FRET IC50 of 26 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CCT369347 (CCT-369347) is potent selective inhibitor of BCL-6 with TR-FRET IC50 of 26 nM.
    CCT369347 demonstrated antiproliferative activity in a panel of BCL6-positive lymphoma cell lines (OCI-Ly1, SU-DHL-4, and SU-DHL-6) with IC50 of 1.68-3.45 uM, with weaker activity against low BCL6 expression cells and noncytotoxocity.
    CCT369347 inhibits BCL6 in a cellular assay with a submicromolar IC50 and shows promising early PK.

    Physicochemical Properties

    M.Wt 485.976
    Formula C26H24ClN7O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-Chloro-4-((4-((2-(5-cyclopropylpyrimidin-2-yl)propan-2-yl)amino)-1-methyl-2-oxo-1,2-dihydroquinolin-6-yl)amino)nicotinonitrile

    References

    1. Matthew G Lloyd, et al. J Med Chem. 2021 Dec 9;64(23):17079-17097.

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