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Chemical Structure : CCT369347
Catalog No.: PC-72519Not For Human Use, Lab Use Only.
CCT369347 (CCT-369347) is potent selective inhibitor of BCL-6 with TR-FRET IC50 of 26 nM.
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CCT369347 (CCT-369347) is potent selective inhibitor of BCL-6 with TR-FRET IC50 of 26 nM.
CCT369347 demonstrated antiproliferative activity in a panel of BCL6-positive lymphoma cell lines (OCI-Ly1, SU-DHL-4, and SU-DHL-6) with IC50 of 1.68-3.45 uM, with weaker activity against low BCL6 expression cells and noncytotoxocity.
CCT369347 inhibits BCL6 in a cellular assay with a submicromolar IC50 and shows promising early PK.
| M.Wt | 485.976 | |
| Formula | C26H24ClN7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Matthew G Lloyd, et al. J Med Chem. 2021 Dec 9;64(23):17079-17097.
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