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Chemical Structure : CCT372064
Catalog No.: PC-38806Not For Human Use, Lab Use Only.
CCT372064 is a potent, ligand-efficient inhibitor of BCL6 with IC50 of 3.9 nM and 12 nM in TR-FRET and cellular NanoBRET assays, respectively.
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CCT372064 is a potent, ligand-efficient inhibitor of BCL6 with IC50 of 3.9 nM and 12 nM in TR-FRET and cellular NanoBRET assays, respectively.
CCT372064 displays antiproliferative activity in BCL6-high OCI-Ly1 and Karpas-422 cell lines with GI50 values of 0.17 and 0.79 uM, and selectivity over the BCL6-low OCI-Ly3 line (GI50=3.4 uM).
| M.Wt | 457.866 | |
| Formula | C22H18ClF2N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Owen A Davis, et al. J Med Chem. 2022 Jun 3. doi: 10.1021/acs.jmedchem.1c02174.
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