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CCT372064

Chemical Structure : CCT372064

CAS No.: 2378852-76-5

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CCT372064 (CCT 372064)

Catalog No.: PC-38806Not For Human Use, Lab Use Only.

CCT372064 is a potent, ligand-efficient inhibitor of BCL6 with IC50 of 3.9 nM and 12 nM in TR-FRET and cellular NanoBRET assays, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CCT372064 is a potent, ligand-efficient inhibitor of BCL6 with IC50 of 3.9 nM and 12 nM in TR-FRET and cellular NanoBRET assays, respectively.
    CCT372064 displays antiproliferative activity in BCL6-high OCI-Ly1 and Karpas-422 cell lines with GI50 values of 0.17 and 0.79 uM, and selectivity over the BCL6-low OCI-Ly3 line (GI50=3.4 uM).

    Physicochemical Properties

    M.Wt 457.866
    Formula C22H18ClF2N5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-2-Chloro-4-((2-cyclopropyl-3,3-difluoro-7-methyl-6-oxo-1,2,3,4,6,7-hexahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl)amino)nicotinonitrile

    References

    1. Owen A Davis, et al. J Med Chem. 2022 Jun 3. doi: 10.1021/acs.jmedchem.1c02174.

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