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Chemical Structure : CCT373566
Catalog No.: PC-38807Not For Human Use, Lab Use Only.
CCT373566 is a highly potent, in vivo active BCL6 degarder with IC50 of 2.2 nM and DC50 of 0.7 nM in TR-FRET and cellular BCL6 degradation assays, respectively.
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CCT373566 is a highly potent, in vivo active BCL6 degarder with IC50 of 2.2 nM and DC50 of 0.7 nM in TR-FRET and cellular BCL6 degradation assays, respectively.
CCT373566 exhibits potent growth inhibition in 14-day proliferative assays of BCL6 dependent DLBCL cell lines, HT, Karpas 422, SU-DHL-4 (GI50 values, 1.4-12.5 nM), but not in the BCL6 low-expressing cell line OCI-Ly3.
CCT373566 is a useful probe suitable for sustained depletion of BCL6 in vivo.
CCT373566 (50 mg/kg, BID) showed modest in vivo efficacy in a lymphoma xenograft mouse model following oral dosing
| M.Wt | 547.004 | |
| Formula | C26H29ClF2N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rosemary Huckvale, et al. J Med Chem. 2022 Jun 2. doi: 10.1021/acs.jmedchem.1c02175.
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