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CCT374705

Chemical Structure : CCT374705

CAS No.: 2640647-90-9

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CCT374705 (CCT 374705)

Catalog No.: PC-20503Not For Human Use, Lab Use Only.

CCT374705 is a potent, selective, in-vivo active BCL6 inhibitor with TR-FRET IC50 of 6 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CCT374705 is a potent, selective, in-vivo active BCL6 inhibitor with TR-FRET IC50 of 6 nM.
    CCT374705 displays high selectivity for BCL-6 and minimal off-target interactions against a kinase panel (468).
    CCT374705 exhibits antiproliferative activity BCL6-dependent cell line OCI-Ly1 and Karpas 422 with GI50 of 38.5 and 12.9 nM, respectively.
    CCT374705 (50 mg/kg PO) demonstrates in vitro efficacyin a Karpas 422 xenograft model in mice, with a significant increase in ARID3A mRNA expression.

    Physicochemical Properties

    M.Wt 450.85
    Formula C21H18ClF3N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    O=C1N(C)C2=C(C=C(NC3=C(Cl)C(F)=NC=C3)C=C2)C4=C1OCC(F)(F)[C@H](C5CC5)N4

    References

    1. Alice C Harnden, et al. J Med Chem. 2023 Apr 7. doi: 10.1021/acs.jmedchem.3c00155.

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