Chemical Structure : CDD-2728
CAS No.:
3061749-63-8
CDD-2728
(CDD2728)
Catalog No.: PC-27741Not For Human Use, Lab Use Only.
CDD-2728 is a potent and selective inhibitor of c-Jun N-terminal kinase (JNK) with Kd of 0.31/3.7/1.6 nM for JNK1/2/3 respectively, IC50 of 0.61/0.57/0.53 nM in NanoBRET intracellular target engagement assays.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CDD-2728 is a potent and selective inhibitor of c-Jun N-terminal kinase (JNK) with Kd of 0.31/3.7/1.6 nM for JNK1/2/3 respectively, IC50 of 0.61/0.57/0.53 nM in NanoBRET intracellular target engagement assays.
CDD-2728 (10 uM) induces dose-dependent reductions in IL1β-mediated phosphorylation of Ser73 (pSer73) and pSer63 JUN phosphorylation in L1β-stimulated 12Z peritoneal endometriotic epithelial cells.
CDD-2728 (5 uM) significantly decreases the expression of MMP3 and IL8 in endometriotic 12Z cells treated with IL1β, with no impact on viability up to 50 uM.
CDD-2728 potently inhibits IL1β-induced expression of IL18, TNC, DUSP8, CREB5, and TRAF1, suppresses inflammatory gene expression in primary derived endometriotic stromal cells.
CDD-2728 (5-25 mg/kg) reduces lesion number and decreases macrophage infiltration and proliferation in an induced mouse model of endometriosis.
Physicochemical Properties
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M.Wt
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456.52
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Formula
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C25H20N4O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(3-(dimethylcarbamoyl)-4-hydroxyphenyl)-4-(1H-pyrrolo[2,3-b]pyridin-5-yl)benzo[b]thiophene-2-carboxamide
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References
1. Madasu C, et al. Proc Natl Acad Sci U S A. 2026 Aug 25;123(34):e2607561123.
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