CDD-2789 | ALK2/ALK1 inhibitor | Probechem Biochemicals

Chemical Structure : CDD-2789

CDD-2789 (CDD2789)

Catalog No.: PC-23416Not For Human Use, Lab Use Only.

CDD-2789 is a highly potent and selective ALK2 (ACVR1)/ALK1 (ACVRL1) kinases inhibitor with Kd of 2.1/3.9 nM.

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Biological Activity

CDD-2789 is a highly potent and selective ALK2 (ACVR1)/ALK1 (ACVRL1) kinases inhibitor with Kd of 2.1/3.9 nM.
CDD-2789 exhibits high selectivity toward ALK2/ALK1 in KINOMEscan analysis and NB K192 assay.
CDD-2789 effectively attenuates activin A and BMP-induced Phosphorylated SMAD1/5 activation in fibroblasts from individuals with FOP in a dose-dependent manner.
CDD-2789 is a valuable tool compound for further investigation of the biological functions of ALK2 and ALK1 and the therapeutic potential of specific inhibition of ALK2.

Physicochemical Properties

M.Wt	466.58
Formula	C26H34N4O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-cyclobutyl-N-(3-(dimethylamino)propyl)-2-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazole-6-carboxamide

References

1. Jimmidi R, et al. Proc Natl Acad Sci U S A. 2024 Nov 19;121(47):e2413108121.

CDD-2789 (CDD2789)

Biological Activity

Physicochemical Properties

References

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