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CDD-3167

Chemical Structure : CDD-3167

CAS No.:

CDD-3167 (CDD3167)

Catalog No.: PC-22283Not For Human Use, Lab Use Only.

CDD-3167 (CDD3167) is a potent, selective pan-ephrin receptor kinase (EPH receptor) inhibitor with binding Ki of 0.13/0.38 nM, cell IC50 of 8.0/2.3 nM for EPHA2/EPHA4, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CDD-3167 (CDD3167) is a potent, selective pan-ephrin receptor kinase (EPH receptor) inhibitor with binding Ki of 0.13/0.38 nM, cell IC50 of 8.0/2.3 nM for EPHA2/EPHA4, respectively.
    CDD-3167 significantly decreases EFNA5 (ligand) induced phosphorylation of EPHA2/4, decreases 12Z cell viability, and decreases IL-1β-mediated expression of prostaglandin synthase 2 (PTGS2) in 12Z endometriotic epithelial cells.
    CDD-3167 decreases expansion of primary endometrial epithelial organoids from patients with endometriosis and decreases Ewing's sarcoma viability.

    Physicochemical Properties

    M.Wt 458.56
    Formula C27H30N4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    5-(5-hydroxy-2-methylphenyl)-6-methyl-N-(2-(4-(methylcarbamoyl)piperidin-1-yl)phenyl)picolinamide

    References

    1. Madasu C, et al. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2322934121.

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