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Chemical Structure : CDD-3167
Catalog No.: PC-22283Not For Human Use, Lab Use Only.
CDD-3167 (CDD3167) is a potent, selective pan-ephrin receptor kinase (EPH receptor) inhibitor with binding Ki of 0.13/0.38 nM, cell IC50 of 8.0/2.3 nM for EPHA2/EPHA4, respectively.
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CDD-3167 (CDD3167) is a potent, selective pan-ephrin receptor kinase (EPH receptor) inhibitor with binding Ki of 0.13/0.38 nM, cell IC50 of 8.0/2.3 nM for EPHA2/EPHA4, respectively.
CDD-3167 significantly decreases EFNA5 (ligand) induced phosphorylation of EPHA2/4, decreases 12Z cell viability, and decreases IL-1β-mediated expression of prostaglandin synthase 2 (PTGS2) in 12Z endometriotic epithelial cells.
CDD-3167 decreases expansion of primary endometrial epithelial organoids from patients with endometriosis and decreases Ewing's sarcoma viability.
| M.Wt | 458.56 | |
| Formula | C27H30N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Madasu C, et al. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2322934121.
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