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CDE 096

Chemical Structure : CDE 096

CAS No.: 1228357-04-7

CDE 096 (CDE096, CDE-096)

Catalog No.: PC-70342Not For Human Use, Lab Use Only.

CDE 096 (CDE-096, CDE096) is a selective, reversible, high-affinity PAI-1 inhibitor that prevents PAI-1 from inactivating tPA and uPA with similar potency (IC50=30 and 25 nM, respectively).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CDE 096 (CDE-096, CDE096) is a selective, reversible, high-affinity PAI-1 inhibitor that prevents PAI-1 from inactivating tPA and uPA with similar potency (IC50=30 and 25 nM, respectively).
CDE 096 shows ineffective against two closely related serpins, antithrombin and α1-PI.
CDE 096 blocks PAI-1 binding to vitronectin with IC50 of 22 nM.

Physicochemical Properties

M.Wt 583.425
Formula C25H20F3NO12
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-(((3-(trifluoromethyl)phenoxy)carbonyl)amino)propane-1,2-diyl bis(3,4,5-trihydroxybenzoate)

References

1. Li SH, et al. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):E4941-9.

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