Chemical Structure : CDK9 degrader AZ-9
CAS No.:
CDK9 degrader AZ-9
Catalog No.: PC-24813Not For Human Use, Lab Use Only.
CDK9 degrader AZ-9 is a potent, ATG101-recruiting selective CDK9 degrader, significantly degrades CDK9 and Cyclin T1 with DC50 of 0.4073 and 1.215 uM in HCT116 cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CDK9 degrader AZ-9 is a potent, ATG101-recruiting selective CDK9 degrader, significantly degrades CDK9 and Cyclin T1 with DC50 of 0.4073 and 1.215 uM in HCT116 cells.
CDK9 degrader AZ-9 shows no significant on other cell cycle CDKs (CDK2, CDK4, and CDK6).
CDK9 degrader AZ-9 promotes classic downstream pathway related to CDK9, induces autophagy–lysosome pathway degradation of CDK9 by recruiting ATG101.
CDK9 degrader AZ-9 (50 mg/kg, po or 20 mg/kg i.p.) shows significant CDK9 degradation and downstream pathway effects in HCT116 xenograft model.
Physicochemical Properties
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M.Wt
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637.56
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Formula
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C32H34Cl2N6O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-(2,6-dichlorobenzamido)-N-(1-(4-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino)-4-oxobutanoyl)piperidin-4-yl)-1H-pyrazole-3-carboxamide
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References
1. Ye Zhong, et al. Acta Pharm Sin B. 2025 May;15(5):2612-2624.
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