Chemical Structure : CDK9 degrader PO-8
CAS No.:
CDK9 degrader PO-8
Catalog No.: PC-25541Not For Human Use, Lab Use Only.
CDK9 degrader PO-8 is a potent, selective iCDK9-based PROTAC degrader of CDK9 with DC50 of 0.26 uM in RAW 264.7 cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CDK9 degrader PO-8 is a potent, selective iCDK9-based PROTAC degrader of CDK9 with DC50 of 0.26 uM in RAW 264.7 cells.
PO-8 does not affect CDKs (CDK1, CDK2, CDK4, CDK6, and CDK7).
PO-8′s degradation mechanism relies on CRBN-mediated ubiquitination.
PO-8 exhibits dose-dependent inhibition of LPS-induced inflammation in RAW264.7 cells.
PO-8 suppresses the JAK2-STAT3 signaling pathway by degrading CDK9
PO-8 (5-10 mg/kg) attenuates LPS-induced acute lung injury in LPS-induced murine acute lung injury (ALI) model, robustly suppresses LPS induced a pronounced upregulation of pro-inflammatory cytokines such as IL-6, IL-1β, and TNF-α.
Physicochemical Properties
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M.Wt
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823.37
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Formula
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C44H48ClFN8O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-((1r,4r)-4-((5'-chloro-6-((3-fluorobenzyl)amino)-[2,4'-bipyridin]-2'-yl)amino)cyclohexyl)-8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)octanamide
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References
1. Ao MT, et al. Biochem Pharmacol. 2025 Sep 19:117341.
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