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Chemical Structure : CDP-840
Catalog No.: PC-63096Not For Human Use, Lab Use Only.
CDP-840 (CDP840;L-765527) is a potent and selective PDE4 inhibitor with IC50 of 4-45 nM for PDE4 extracted from tissues or recombinant PDE 4 isoforms expressed in yeast.
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CDP-840 (CDP840;L-765527) is a potent and selective PDE4 inhibitor with IC50 of 4-45 nM for PDE4 extracted from tissues or recombinant PDE 4 isoforms expressed in yeast.
CDP-840 shows no effect for PDE-1, 2, 3, 5, and 7 (IC50>100 uM), exhibits no significant selectivity in inhibiting human recombinant isoenzymes PDE-4A, B, C or D and is equally active against the isoenzymes lacking UCR1 (PDE-4B2 and PDE-4D2).
CDP-840 causes a dose-dependent reduction of IL-5-induced pleural eosinophilia in rats (ED50=0.03 mg/kg).
CDP-840 prevents antigen-induced eosinophilia and bronchoconstriction; orally active.
| M.Wt | 373.496 | |
| Formula | C25H27NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hughes B, et al. Br J Pharmacol. 1996 Jul;118(5):1183-91.
2. Holbrook M, et al. Br J Pharmacol. 1996 Jul;118(5):1192-200.
3. Perry MJ, et al. Cell Biochem Biophys. 1998;29(1-2):113-32.
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