CDP-840 hydrochloride | Probechem Biochemicals

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Chemical Structure : CDP-840 hydrochloride

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CDP-840 hydrochloride (CDP840;L-765527;GR259653X)

Catalog No.: PC-63097Not For Human Use, Lab Use Only.

CDP-840 (CDP840.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CDP-840 (CDP840;L-765527) hydrochloride is a potent and selective PDE4 inhibitor with IC50 of 4-45 nM for PDE4 extracted from tissues or recombinant PDE 4 isoforms expressed in yeast.

CDP-840 shows no effect for PDE-1, 2, 3, 5, and 7 (IC50>100 uM), exhibits no significant selectivity in inhibiting human recombinant isoenzymes PDE-4A, B, C or D and is equally active against the isoenzymes lacking UCR1 (PDE-4B2 and PDE-4D2).

CDP-840 causes a dose-dependent reduction of IL-5-induced pleural eosinophilia in rats (ED50=0.03 mg/kg).

CDP-840 prevents antigen-induced eosinophilia and bronchoconstriction; orally active.

Physicochemical Properties

M.Wt	409.95
Formula	C25H27NO2.HCl
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[(2R)-2-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-phenylethyl]-pyridine hydrochloride

References

1. Hughes B, et al. Br J Pharmacol. 1996 Jul;118(5):1183-91.

2. Holbrook M, et al. Br J Pharmacol. 1996 Jul;118(5):1192-200.

3. Perry MJ, et al. Cell Biochem Biophys. 1998;29(1-2):113-32.

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CDP-840 hydrochloride (CDP840;L-765527;GR259653X)

Biological Activity

Physicochemical Properties

References

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