Chemical Structure : CDRI-1709S
CAS No.:
CDRI-1709S
Catalog No.: PC-27859Not For Human Use, Lab Use Only.
CDRI-1709S is a highly potent, selective small molecule AdipoR1 (Adiponectin receptor 1) with EC50 of 414.7 pM, activates adiponectin signalling via AdipoR1 but not AdipoR2.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CDRI-1709S is a highly potent, selective small molecule AdipoR1 (Adiponectin receptor 1) agonist with EC50 of 414.7 pM, activates adiponectin signalling via AdipoR1 but not AdipoR2.
CDRI‐1709S promoted C2C12 myoblast differentiation into mature myotubes, accompanied by increased expression of MyoD and myogenin.
CDRI‐1709S also reverses Dexamethasone‐mediated impairments in oxidative and glycolytic capacity.
CDRI‐1709S activated hallmark adiponectin‐associated signalling events, including phosphorylation of AMPK, AKT and p38‐MAPK, in AdipoR1‐overexpressing HEK293T and AdipoR‐rich C2C12 myotubes.
CDRI‐1709S protected myotubes against Dexamethasone, LPS + TNFα and PBS (nutrient deficiency)‐induced atrophy.
CDRI‐1709S prevented dexamethasone‐induced skeletal muscle atrophy in SD rats.
Physicochemical Properties
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M.Wt
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262.24
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Formula
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C15H11NaO3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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sodium 6a,11a-dihydro-6H-benzofuro[3,2-c]chromen-3-olate
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References
1. Md Rameez Moin, et al. J Cachexia Sarcopenia Muscle. 2026 Aug;17(4):e70328.
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