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Chemical Structure : CEP-28122
Catalog No.: PC-45404Not For Human Use, Lab Use Only.
CEP-28122 is a highly potent and selective, orally active ALK inhibitor with IC50 of 1.9 nM.
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CEP-28122 is a highly potent and selective, orally active ALK inhibitor with IC50 of 1.9 nM.
CEP-28122 exhibits no-to-weak inhibition against a panel of 259 kinases and only 15 kinases showes >90% inhibition at 1 uM.
CEP-28122 shows growth inhibition/cytotoxicity of ALCL, NSCLC, and neuroblastoma cells, and displays dose-dependent inhibition of ALK tyrosine phosphorylation in tumor xenografts in mice (30 mg/kg).
| M.Wt | 539.0689 | |
| Formula | C28H35ClN6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cheng M, et al. Mol Cancer Ther. 2012 Mar;11(3):670-9.
2. Sullivan I, et al. Ther Adv Med Oncol. 2016 Jan;8(1):32-47.
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