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Chemical Structure : CEP-28122 mesylate
CAS No.: 2070009-30-0
Catalog No.: PC-45405Not For Human Use, Lab Use Only.
CEP-28122 mesylate is a highly potent and selective, orally active ALK inhibitor with IC50 of 1.9 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $228 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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CEP-28122 mesylate is a highly potent and selective, orally active ALK inhibitor with IC50 of 1.9 nM.
CEP-28122 mesylate exhibits no-to-weak inhibition against a panel of 259 kinases and only 15 kinases showes >90% inhibition at 1 uM.
CEP-28122 mesylate shows growth inhibition/cytotoxicity of ALCL, NSCLC, and neuroblastoma cells, and displays dose-dependent inhibition of ALK tyrosine phosphorylation in tumor xenografts in mice (30 mg/kg).
| M.Wt | 635.1746 | |
| Formula | C29H39ClN6O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 6.4 mg/mL; DMSO < 9.2 mg/mL |
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| Chemical Name/SMILES |
Bicyclo[2.2.1]hept-5-ene-2-carboxamide, 3-[[5-chloro-2-[[(7S)-6,7,8,9-tetrahydro-1-methoxy-7-(4-morpholinyl)-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-, (1S,2S,3R,4R)-, methanesulfonate (1:1) |
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1. Cheng M, et al. Mol Cancer Ther. 2012 Mar;11(3):670-9.
2. Sullivan I, et al. Ther Adv Med Oncol. 2016 Jan;8(1):32-47.
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