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CEP-40783

Chemical Structure : CEP-40783

CAS No.: 1437321-24-8

CEP-40783 (CEP 40783;CEP40783;RXDX-106)

Catalog No.: PC-42292Not For Human Use, Lab Use Only.

CEP-40783 (CEP40783, RXDX-106) is a potent and selective AXL/c-Met inhibitor with IC50 of 7 nM/12 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CEP-40783 (CEP40783, RXDX-106) is a potent and selective AXL/c-Met inhibitor with IC50 of 7 nM/12 nM.
CEP-40783 displays kinome selectivity against 298 kinases.
CEP-40783 is 27-fold more active compared to recombinant enzyme with IC50 of 0.26 nM in AXL transfected 293GT cells.
CEP-40783 shows superior activity against c-Met in GTL-16 cells (IC50=6 nM); orally active in cancer models.

Physicochemical Properties

M.Wt 588.5581464
Formula C31H26F2N4O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 7.6 mg/mL

Chemical Name/SMILES

5-Pyrimidinecarboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-3-(4-fluorophenyl)-1,2,3,4-tetrahydro-1-(1-methylethyl)-2,4-dioxo-

References

1. Kim JE, et al. Oncotarget. 2017 Nov 11;8(62):105727-105734.

2. Yokoyama Y, et al. Cancer Res. 2019 Feb 5. pii: canres.2022.2018. doi: 10.1158/0008-5472.CAN-18-2022.

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