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Chemical Structure : CEP-40783
CAS No.: 1437321-24-8
Catalog No.: PC-42292Not For Human Use, Lab Use Only.
CEP-40783 (CEP40783, RXDX-106) is a potent and selective AXL/c-Met inhibitor with IC50 of 7 nM/12 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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CEP-40783 (CEP40783, RXDX-106) is a potent and selective AXL/c-Met inhibitor with IC50 of 7 nM/12 nM.
CEP-40783 displays kinome selectivity against 298 kinases.
CEP-40783 is 27-fold more active compared to recombinant enzyme with IC50 of 0.26 nM in AXL transfected 293GT cells.
CEP-40783 shows superior activity against c-Met in GTL-16 cells (IC50=6 nM); orally active in cancer models.
| M.Wt | 588.5581464 | |
| Formula | C31H26F2N4O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 7.6 mg/mL |
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| Chemical Name/SMILES |
5-Pyrimidinecarboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-3-(4-fluorophenyl)-1,2,3,4-tetrahydro-1-(1-methylethyl)-2,4-dioxo- |
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1. Kim JE, et al. Oncotarget. 2017 Nov 11;8(62):105727-105734.
2. Yokoyama Y, et al. Cancer Res. 2019 Feb 5. pii: canres.2022.2018. doi: 10.1158/0008-5472.CAN-18-2022.
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