CEP-751 | Trk inhibitor | ProbeChem Biochemicals

Chemical Structure : CEP-751

CEP-751 (KT-6587, KT 6587, CEP 751)

Catalog No.: PC-70172Not For Human Use, Lab Use Only.

CEP-751 (KT-6587) is potent inhibitor of TrkA with IC50 of 2.9 nM, also inhibits TrkB, TrkC.

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Biological Activity

CEP-751 (KT-6587) is potent inhibitor of TrkA with IC50 of 2.9 nM, also inhibits TrkB, TrkC.
CEP-751 (KT-6587) shows weak inhibition for PDGFR and bFGFR, has no effect on EGF, IGF-I, insulin, ErbB receptors.
CEP-751 (KT-6587) exhibits anti-tumor efficacy against tumors derived from NIH3T3 cells transfected with trkA.
CEP-751 (KT-6587) inhibits tumor growth in MTC cell xenografts.

Physicochemical Properties

M.Wt	453.4957
Formula	C27H23N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5R,7S,8S)-7-(hydroxymethyl)-7-methoxy-5,6,7,8,13,14-hexahydro-15H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacen-15-one

References

1. Camoratto AM, et al. Int J Cancer. 1997 Aug 7;72(4):673-9.

2. Dionne CA, et al. Clin Cancer Res. 1998 Aug;4(8):1887-98.

3. Strock CJ, et al. Cancer Res. 2003 Sep 1;63(17):5559-63.

CEP-751 (KT-6587, KT 6587, CEP 751)

Biological Activity

Physicochemical Properties

References

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