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Chemical Structure : CEP-751
Catalog No.: PC-70172Not For Human Use, Lab Use Only.
CEP-751 (KT-6587) is potent inhibitor of TrkA with IC50 of 2.9 nM, also inhibits TrkB, TrkC.
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CEP-751 (KT-6587) is potent inhibitor of TrkA with IC50 of 2.9 nM, also inhibits TrkB, TrkC.
CEP-751 (KT-6587) shows weak inhibition for PDGFR and bFGFR, has no effect on EGF, IGF-I, insulin, ErbB receptors.
CEP-751 (KT-6587) exhibits anti-tumor efficacy against tumors derived from NIH3T3 cells transfected with trkA.
CEP-751 (KT-6587) inhibits tumor growth in MTC cell xenografts.
| M.Wt | 453.4957 | |
| Formula | C27H23N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Camoratto AM, et al. Int J Cancer. 1997 Aug 7;72(4):673-9.
2. Dionne CA, et al. Clin Cancer Res. 1998 Aug;4(8):1887-98.
3. Strock CJ, et al. Cancer Res. 2003 Sep 1;63(17):5559-63.
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