Chemical Structure : CF3CN
CAS No.:
2410598-89-7
CF3CN
(CF3-CN)
Catalog No.: PC-28351Not For Human Use, Lab Use Only.
CF3CN is a brain permeable, synthetic 7,8-DHF derivative and TrkB agonist, robustly binds to the LCM/CC2 motif on TrkB extracellular domain (ECD) with Kd of 80.2 nM, activates TrkB and its downstream signaling pathway.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CF3CN is a brain permeable, synthetic 7,8-DHF derivative and TrkB agonist, robustly binds to the LCM/CC2 motif on TrkB extracellular domain (ECD) with Kd of 80.2 nM, activates TrkB and its downstream signaling pathway.
CF3CN displays a dose-dependent protection against staurosporine-induced apoptosis in T48 cells with EC50 around 26.4 nM.
CF3CN protects BR6 cells from STS-induced cell death with IC50 of 103 nM, but not TrkB-deficient SH-SY5Y cells.
CF3CN activates p-TrkB and promotes cell survival in a TrkB-dependent manner.
CF3CN dose-dependently decreases Aβ42, prevents the synaptic loss in the hippocampus in 5xFAD mouse brains.
CF3CN alleviates inflammation, inhibits delta-secretase (AEP, δ-secretase) activation, and reduces the concentrations of AEP-derived APP fragments and Tau fragments.
Physicochemical Properties
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M.Wt
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355.28
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Formula
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C18H8F3N3O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-(6-oxo-2-(trifluoromethyl)-3,6-dihydrochromeno[7,8-d]imidazol-8-yl)benzonitrile
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References
1. Chun Chen, et al. ACS Chem Neurosci. 2021 Jul 7;12(13):2448-2461.
2. Jianming Liao, et al. Neuropharmacology. 2021 Oct 1:197:108737.
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