CFMB (FFAR2 agonist 58) is a potent, allosteric FFAR2 (GPR43) agonist / modulator with EC50 of 0.8 uM for hFFAR2 and 0.2 uM for rFFAR2.
CFMB functions as a positive/priming modulator in these cells by turning the natural FFA2R agonist acetate into a potent activator of the neutrophil NADPH-oxidase.
CFMB lowers the concentration of acetate required to induce a transient rise in the concentration of intracellular Ca2+ in neutrophils, has no direct effect on the neutrophil NADPH-oxidase activity but affects the response induced by acetate.
CFMB significantly reduced the amount of internalized influenza A virus (IAV) in treated A549 cells.
