CFMB (FFA2R agonist 58) is a potent, allosteric FFAR2 (GPR43) agonist/modulator.
FFA2R agonist 58 functions as a positive/priming modulator in these cells by turning the natural FFA2R agonist acetate into a potent activator of the neutrophil NADPH-oxidase.
FFA2R agonist 58 lowers the concentration of acetate required to induce a transient rise in the concentration of intracellular Ca2+ in neutrophils, has no direct effect on the neutrophil NADPH-oxidase activity but affects the response induced by acetate.
FFA2R agonist 58 significantly reduced the amount of internalized influenza A virus (IAV) in treated A549 cells.
