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Chemical Structure : CFT-14441
Catalog No.: PC-73310Not For Human Use, Lab Use Only.
CFT-14441 is a potent and selective BRD9 BiDAC degrader with DC50 of 39 nM (2h), high selectivity over BRD4 abd BRD7.
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CFT-14441 is a potent and selective BRD9 BiDAC degrader with DC50 of 39 nM (2h), high selectivity over BRD4 abd BRD7.
CFT-14441 efficiently degrades endogenous BRD9 in the Yamato-SS synovial sarcoma cell line, results in growth inhibition of BAF-perturbed HSSYII synovial sarcoma cells but not BAF-wild type SW982 soft tissue sarcoma cells.
CFT-14441 demonstrates efficacy in both cell-derived and patient-derived models of synovial sarcoma (IV or IP dosing).
| M.Wt | 724.819 | |
| Formula | C38H44N8O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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