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Chemical Structure : CFT8634
CAS No.: 2704617-96-7
Catalog No.: PC-73316Not For Human Use, Lab Use Only.
CFT-8634 (CFT8634) is a potent, selective, orally bioavailable BRD9 BiDAC degrader with DC50 of 3 nM, high selectivity over BRD4 abd BRD7.
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CFT-8634 (CFT8634) is a potent, selective, orally bioavailable BRD9 BiDAC degrader with DC50 of 3 nM, high selectivity over BRD4 abd BRD7.
Unlike BRD9 inhibition, BRD9 degradation is efficacious in preclinical models of synovial sarcoma and CFT8634 is ongoing for the treatment of SMARCB1-perturbed cancers.
| M.Wt | 710.799 | |
| Formula | C37H45F3N6O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3S)-3-[[4-[4-[(4S)-1-[[4-(1,6-Dihydro-1,4,5-trimethyl-6-oxo-3-pyridinyl)-2,6-dimethoxyphenyl]methyl]-3,3-difluoro-4-piperidinyl]-1-piperazinyl]-3-fluorophenyl]amino]-2,6-piperidinedione |
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1. Patent WO2021178920A1.
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