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CGH2466

Chemical Structure : CGH2466

CAS No.: 252198-68-8

CGH2466 (CGH-2466;CGH 2466)

Catalog No.: PC-61085Not For Human Use, Lab Use Only.

CGH2466 is a combined adenosine receptor antagonist, p38 MAPK and PDE4 inhibitor, inhibits A1, A2b and A3 receptor (IC50=19, 21 and 80 nM), p38α, p38β and PDE4D (IC50=87, 400 and 22 nM).

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    Biological Activity

    CGH2466 is a combined adenosine receptor antagonist, p38 MAPK and PDE4 inhibitor, inhibits A1, A2b and A3 receptor (IC50=19, 21 and 80 nM), p38α, p38β and PDE4D (IC50=87, 400 and 22 nM).
    CGH2466 more potently (IC50=30-50 nM) inhibits the production of cytokines and oxygen radicals by human peripheral blood leucocytes in vitro than SB203580 (IC50>1 uM).
    CGH2466 inhibits the ovalbumin- or lipopolysaccharide-induced airway inflammation in mice more potently.
    CGH2466 also shows potent binding affinity (Kb=48 nM) for GPR68.

    Physicochemical Properties

    M.Wt 322.207
    Formula C14H9Cl2N3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-amino-4-(3,4-dichlorophenyl)-5-pyridin-4-yl-thiazol

    References

    1. Trifilieff A, et al. Br J Pharmacol. 2005 Apr;144(7):1002-10.

    2. Huang XP, et al. Nature. 2015 Nov 26;527(7579):477-83.

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