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Chemical Structure : CGH2466
Catalog No.: PC-61085Not For Human Use, Lab Use Only.
A combined adenosine receptor antagonist, p38 MAPK and PDE4 inhibitor, inhibits A1, A2b and A3 receptor (IC50=19, 21 and 80 nM), p38α, p38β and PDE4D (IC50=87, 400 and 22 nM).
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A combined adenosine receptor antagonist, p38 MAPK and PDE4 inhibitor, inhibits A1, A2b and A3 receptor (IC50=19, 21 and 80 nM), p38α, p38β and PDE4D (IC50=87, 400 and 22 nM); more potently (IC50=30-50 nM) inhibits the production of cytokines and oxygen radicals by human peripheral blood leucocytes in vitro than SB203580 (IC50>1 uM); inhibits the ovalbumin- or lipopolysaccharide-induced airway inflammation in mice more potently; also shows potent binding affinity (Kb=48 nM) for GPR68.
| M.Wt | 322.207 | |
| Formula | C14H9Cl2N3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Trifilieff A, et al. Br J Pharmacol. 2005 Apr;144(7):1002-10.
2. Huang XP, et al. Nature. 2015 Nov 26;527(7579):477-83.
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