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Chemical Structure : CGI-1746
CAS No.: 910232-84-7
Catalog No.: PC-42817Not For Human Use, Lab Use Only.
CGI-1746 is a potent, highly selective, second-generation BTK inhibitor with IC50 of 1.9 nM, displays 1,000-fold selectivity over Tec and Src family kinases.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote | ||
| 1 g | Get quote |
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CGI-1746 is a potent, highly selective, second-generation BTK inhibitor with IC50 of 1.9 nM, displays 1,000-fold selectivity over Tec and Src family kinases.
CGI-1746 displays no significant binding affinity for other 385 kinases.
CGI-1746 abolishes FcγRIII-induced TNFα, IL-1β and IL-6 production in macrophages, blocks B cell receptor-dependent B cell proliferation and in prophylactic regimens reduces autoantibody levels in collagen-induced arthritis.
CGI-1746 inhibits myeloma-like tumors both in vitro and in vivo.
| M.Wt | 579.6887 | |
| Formula | C34H37N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzamide, N-[3-[4,5-dihydro-4-methyl-6-[[4-(4-morpholinylcarbonyl)phenyl]amino]-5-oxo-2-pyrazinyl]-2-methylphenyl]-4-(1,1-dimethylethyl)- |
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1. Di Paolo JA, et al. Nat Chem Biol. 2011 Jan;7(1):41-50.
2. Young WB, et al. Bioorg Med Chem Lett. 2015 Mar 15;25(6):1333-7.
3. Yang Y, et al. Cancer Res. 2015 Feb 1;75(3):594-604.
4. Kokabee L, et al. Cancer Biol Ther. 2015;16(11):1604-15.
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