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Chemical Structure : CGK1026
Catalog No.: PC-70244Not For Human Use, Lab Use Only.
CGK1026 is a small molecule that inhibits human telomerase reverse transcriptase (hTERT) expression, inhibits HDAC activity with IC50 of 100 nM.
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CGK1026 is a small molecule that inhibits human telomerase reverse transcriptase (hTERT) expression, inhibits HDAC activity with IC50 of 100 nM.
CGK1026 inhibits the recruitment of HDAC into E2F-pocket protein complexes assembled on the hTERT promoter,.
CGK1026 induces G1 arrest of IMR90 cells.
| M.Wt | 326.352 | |
| Formula | C18H18N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Won J, et al. Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11328-33.
2. Alimirah F, et al. Mol Cancer Res. 2007 Mar;5(3):251-9.
3. Song LL, et al. PLoS One. 2010 Jan 5;5(1):e8569.
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