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Chemical Structure : CGK733
CAS No.: 905973-89-9
Catalog No.: PC-21522Not For Human Use, Lab Use Only.
CGK733 is a specific small molecule inhibitor of ATM and ATR kinases, induces cell death in prematurely senescent breast cancer cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $178 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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CGK733 is a specific small molecule inhibitor of ATM and ATR kinases, induces cell death in prematurely senescent breast cancer cells.
CGK733 decreases p21CIP1 levels in premature senescent MCF-7 and HCT-116 cells, also exhibits antiproliferative activity in a range of cancer cell lines.
CGK733 blocks camptothecin-induced p53 phosphorylation and protects cells from camptothecin-induced apoptosis.
| M.Wt | 555.83 | |
| Formula | C23H18Cl3FN4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
α-Phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]benzeneacetamide |
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1. Won J, et al. Nat Chem Biol. 2006 Jul;2(7):369-74.
2. Crescenzi E, et al. Clin Cancer Res. 2008 Mar 15;14(6):1877-87.
3. Bhattacharya S, et al. Cell Signal. 2009 Apr;21(4):509-22.
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