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CH5447240

Chemical Structure : CH5447240

CAS No.: 1253919-92-4

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CH5447240 (CH-5447240)

Catalog No.: PC-35255Not For Human Use, Lab Use Only.

CH5447240 is a novel potent, selective, orally active hPTHR1 agonist with EC20 of 3.0 nM and EC50 of 12 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CH5447240 is a novel potent, selective, orally active hPTHR1 agonist with EC20 of 3.0 nM and EC50 of 12 nM.
    CH5447240 shows excellent physicochemical properties, such as high solubility in fasted state simulated intestinal fluid and good metabolic stability in human liver microsomes.
    CH5447240 demonstrates a significantly elevated serum calcium level in hypocalcemic model rats.

    Physicochemical Properties

    M.Wt 517.689
    Formula C26H39N5O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(3,5-dimethyl-4-(2-((2-((1R,4R)-4-methylcyclohexyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-1-methylurea

    References

    1. Nishimura Y, et al. J Med Chem. 2018 Jun 22. doi: 10.1021/acs.jmedchem.8b00182.

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