CHF-6523 | PI3Kδ inhibitor | Probechem Biochemicals

Chemical Structure : CHF-6523

CHF-6523 (CHF6523)

Catalog No.: PC-23222Not For Human Use, Lab Use Only.

CHF-6523 is a potent, selective and inhaled PI3Kδ inhibitor with enzymatic pKi value of 9.07 and pIC50 of 8.78 in THP-1 assay.

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Biological Activity

CHF-6523 is a potent, selective and inhaled PI3Kδ inhibitor with enzymatic pKi value of 9.07 and pIC50 of 8.78 in THP-1 assay.

CHF-6523 displays >100-fold selectivity over PI3Kα/β/γ.

CHF-6523 displays durable anti-inflammatory activity in a disease-relevant rat model of Th-2-driven acute lung inflammation and safe in vitro and in vivo preclinical profiles.

CHF-6523 exhibits potential for obstructive pulmonary disease (COPD).

Physicochemical Properties

M.Wt	588.67
Formula	C33H32N8O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[(1S)-1-[4-Amino-3-(5-hydroxy-3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-4-[3-[(4-methyl-1-piperazinyl)methyl]phenyl]-1H-2-benzopyran-1-one

References

1. Mirco Govoni, et al. Respir Res. 2024 Oct 19;25(1):380.
2. Bruno P, et al. J Med Chem. 2024 Dec 5. doi: 10.1021/acs.jmedchem.4c02062.

CHF-6523 (CHF6523)

Biological Activity

Physicochemical Properties

References

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