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CHF6001

Chemical Structure : CHF6001

CAS No.: 1239278-59-1

CHF6001 (Tanimilast;CHF-6001;CHF 6001)

Catalog No.: PC-60725Not For Human Use, Lab Use Only.

Tanimilast (CHF6001) is a novel, highly potent and selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 0.026 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Tanimilast (CHF6001) is a novel, highly potent and selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 0.026 nM.
CHF6001 inhibits PDE4 isoforms A-D with equal potency, 7- and 923-fold more potent than roflumilast and cilomilast, and displays >20,000-fold selectivity versus PDE4 compared with a panel of PDEs.
CHF6001 effectively inhibits (subnanomolar IC50 values) the release of TNF-α from human PBMCs, THP-1, and rodent macrophages.
CHF6001 inhibitsLPS-induced pulmonary neutrophilia (ED50=0.205 uM/kg) and leukocyte infiltration (ED50=0.188 uM/kg) in rats.

Physicochemical Properties

M.Wt 687.533
Formula C30H30Cl2F2N2O8S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3-(cyclopropylmethoxy)-4-(methylsulfonamido)benzoyloxy)ethyl)pyridine 1-oxide

References

1. Armani E, et al. J Med Chem. 2014 Feb 13;57(3):793-816.

2. Villetti G, et al .J Pharmacol Exp Ther. 2015 Mar;352(3):568-78.

3. Moretto N, et al. J Pharmacol Exp Ther. 2015 Mar;352(3):559-67.

4. Edwards MR, et al. Pharmacol Res Perspect. 2016 Jan 15;4(1):e00202.

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