CHI3L1 inhibitor 11g

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Chemical Structure : CHI3L1 inhibitor 11g

Catalog No.: PC-24878Not For Human Use, Lab Use Only.

CHI3L1 inhibitor 11g is a potent, selective CHI3L1 (chitinase-3-like protein 1) inhibitor with SPR Kd of 13.76 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CHI3L1 inhibitor 11g is a potent, selective CHI3L1 (chitinase-3-like protein 1) inhibitor with SPR Kd of 13.76 uM.
CHI3L1 inhibitor 11g exhibits a dose-dependent response in SPR with Kd of 13.5 uM, but not K284 (Cat# PC-47042).
CHI3L1 inhibitor 11g shows promising antitumor activity in 3D spheroid model of glioblastoma.
CHI3L1 inhibitor 11g reveals excellent pharmacokinetic profile, minimal toxicity, and potential for brain penetration.

Physicochemical Properties

M.Wt	563.67
Formula	C30H33N3O6S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((3-(3,4-dimethoxyphenethyl)-6,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)thio)-N-(4-ethylphenyl)acetamide

References

1. Baljit Kaur, et al. Eur J Med Chem. 2025 Jun 28:297:117924.

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