CHI3L1 inhibitor 30

Chemical Structure : CHI3L1 inhibitor 30

Catalog No.: PC-21914Not For Human Use, Lab Use Only.

CHI3L1 inhibitor 30 is a potent, selective chitinase-3-like-1 (CHI3L1, YKL-40) inhibitor with IC50 of 50 nM, with little to no activity against hCHIT1 and hAMCase (IC50=6500 and 964 nM).

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Biological Activity

CHI3L1 inhibitor 30 is a potent, selective chitinase-3-like-1 (CHI3L1, YKL-40) inhibitor with IC50 of 50 nM, with little to no activity against hCHIT1 and hAMCase (IC50=6500 and 964 nM).

Physicochemical Properties

M.Wt	420.38
Formula	C22H27Cl2N3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,5S)-5-(4-chlorobenzyl)-4-(1-(4-chloropyridin-2-yl)piperidin-4-yl)-2-methylmorpholine

References

1. Czestkowski W, et al. J Med Chem. 2024.

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