CHI3L1 inhibitor G28

Chemical Structure : CHI3L1 inhibitor G28

CAS No.: 1207253-08-4

Catalog No.: PC-24717Not For Human Use, Lab Use Only.

CHI3L1 inhibitor G28 is a potent small molecule CHI3L1 binder/inhibitor with KD of 51.4 uM.

Packing	Price	Stock
5 mg	$158	In stock
10 mg	$248	In stock
25 mg	$428	In stock
100 mg		Get quote

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Biological Activity

CHI3L1 inhibitor G28 is a potent small molecule CHI3L1 binder/inhibitor with KD of 51.4 uM.
G28 significantly outperformed reported CHI3L1 small molecule modulators, showing the most pronounced dose-dependent reductions in spheroid weight, migration, and viability in 3D GBM spheroid models.

Physicochemical Properties

M.Wt	461.91
Formula	C24H20ClN5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	[2,2':5',3''-Terpyridine]-3'-carboxamide, 5''-chloro-N-[(5,6-dimethoxy-2-pyridinyl)methyl]-

References

1. Hossam Nada, et al. bioRxiv [Preprint]. 2025 May 17:2025.05.13.653859.

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