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CHMFL-ABL-053

Chemical Structure : CHMFL-ABL-053

CAS No.: 1808287-83-3

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CHMFL-ABL-053 (ABL-053)

Catalog No.: PC-63026Not For Human Use, Lab Use Only.

CHMFL-ABL-053 is a potent, selective and orally available Bcr-Abl/Src/p38 kinase inhibitor with IC50 of 70/62/90 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CHMFL-ABL-053 is a potent, selective and orally available Bcr-Abl/Src/p38 kinase inhibitor with IC50 of 70/62/90 nM.
    CHMFL-ABL-053 shows no inhibitory activity against c-Kit (>10 uM).
    CHMFL-ABL-053 inhibits the proliferation of CML cell lines K562 (GI50=14 nM), KU812 (GI50=25 nM), and MEG-01 (GI50=16 nM).
    CHMFL-ABL-053 completely suppresses tumor progression in the K562 cells inoculated xenograft mouse model with 50 mg/kg/day dosage treatment.

    Physicochemical Properties

    M.Wt 549.558
    Formula C28H26F3N7O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((3-Amino-4-methylphenyl)amino)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide

    References

    1. Liang X, et al. J Med Chem. 2016 Mar 10;59(5):1984-2004.

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