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Chemical Structure : CHMFL-ABL-053
Catalog No.: PC-63026Not For Human Use, Lab Use Only.
CHMFL-ABL-053 is a potent, selective and orally available Bcr-Abl/Src/p38 kinase inhibitor with IC50 of 70/62/90 nM.
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CHMFL-ABL-053 is a potent, selective and orally available Bcr-Abl/Src/p38 kinase inhibitor with IC50 of 70/62/90 nM.
CHMFL-ABL-053 shows no inhibitory activity against c-Kit (>10 uM).
CHMFL-ABL-053 inhibits the proliferation of CML cell lines K562 (GI50=14 nM), KU812 (GI50=25 nM), and MEG-01 (GI50=16 nM).
CHMFL-ABL-053 completely suppresses tumor progression in the K562 cells inoculated xenograft mouse model with 50 mg/kg/day dosage treatment.
| M.Wt | 549.558 | |
| Formula | C28H26F3N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Liang X, et al. J Med Chem. 2016 Mar 10;59(5):1984-2004.
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