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CHMFL-BMX-078

Chemical Structure : CHMFL-BMX-078

CAS No.: 1808288-51-8

CHMFL-BMX-078 (BMX kinase inhibitor)

Catalog No.: PC-35179Not For Human Use, Lab Use Only.

CHMFL-BMX-078 is a highly selective, potent, type II irreversible BMX kinase inhibitor with IC50 of 11 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CHMFL-BMX-078 is a highly selective, potent, type II irreversible BMX kinase inhibitor with IC50 of 11 nM.
CHMFL-BMX-078 displays a high selectivity profile (S score(1) = 0.01) against the 468 kinases/mutants in the KINOMEscan evaluation and achieved at least 40-fold selectivity over BTK kinase.
CHMFL-BMX-078 is a useful pharmacological tool to elucidate the detailed mechanism of BMX mediated signaling pathways.

Physicochemical Properties

M.Wt 625.686
Formula C33H35N7O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-((3-Acrylamido-4-methylphenyl)amino)-N-(2-methyl-5-(3,4,5-trimethoxybenzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide

References

1. Liang X, et al. J Med Chem. 2017 Mar 9;60(5):1793-1816.

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