CHR-3464 | p38α inhibitor | Probechem Biochemicals

Chemical Structure : CHR-3464

Catalog No.: PC-24997Not For Human Use, Lab Use Only.

CHR-3464 is a potent, selective p38α MAPK inhibitor with IC50 of 1.86 nM, inhibits the production of TNF-α from THP-1 cells with IC50 of 1.5 nM.

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Biological Activity

CHR-3464 is a potent, selective p38α MAPK inhibitor with IC50 of 1.86 nM, inhibits the production of TNF-α from THP-1 cells with IC50 of 1.5 nM.

M.Wt	362.28
Formula	C18H10F4N2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-amino-5-(2,4-difluorobenzoyl)-1-(2,6-difluorophenyl)pyridin-2(1H)-one

1. Needham LA, et al. J Pharmacol Exp Ther. 2011 Oct;339(1):132-42.

2. Charlton, Michael H, et al. MedChemComm (2012), 3(9), 1070-1076.