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Chemical Structure : CHR-3996
CAS No.: 1256448-47-1
Catalog No.: PC-36094Not For Human Use, Lab Use Only.
CHR-3996 (Nanatinostat, VRx-3996, CHR3996, Tractinostat) is a potent, class I-selective, orally active HDAC inhibitor with IC50 of 3-7 nM for HDAC1/2/3.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $378 | In stock | |
| 10 mg | $578 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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CHR-3996 (Nanatinostat, VRx-3996, CHR3996, Tractinostat) is a potent, class I-selective, orally active HDAC inhibitor with IC50 of 3-7 nM for HDAC1/2/3.
CHR-3996 displays little to no activity against HDAC5 and HDAC6 (IC50=200-2000 nM).
CHR-3996 demonstrates growth inhibition of HCT116 cells with GI50 of 72 nM, shows efficacy in human tumor xenograft and exhibits good activity in combination with other anticancer agents.
| M.Wt | 394.41 | |
| Formula | C20H19FN6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[(1R,5S,6s)-6-{[(6-fluoroquinolin-2-yl)methyl]amino}-3-azabicyclo[3.1.0]hexan-3-yl]-N-hydroxypyrimidine-5-carboxamide |
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1. Moffat D, et al. J Med Chem. 2010 Dec 23;53(24):8663-78.
2. Banerji U, et al. Clin Cancer Res. 2012 May 1;18(9):2687-94.
3. Smith EM, et al. Oncotarget. 2015 Jul 10;6(19):17314-27.
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