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Chemical Structure : CI-1044
CAS No.: 197894-84-1
Catalog No.: PC-62897Not For Human Use, Lab Use Only.
CI-1044 is a potent, selective and orally bioavailable PDE4 inhibitor with IC50 of 0.27 uM, displays high selectivity for PDE4 versus PDE1/3/5, and no PDE4 subtype (4A-D) selectivities.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $288 | In stock | |
| 10 mg | $458 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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CI-1044 is a potent, selective and orally bioavailable PDE4 inhibitor with IC50 of 0.27 uM, displays high selectivity for PDE4 versus PDE1/3/5, and no PDE4 subtype (4A-D) selectivities.
CI-1044 exhibits efficient in vitro inhibition of TNFα release from hPBMC and hWB with IC50 of 0.34 and 0.84 uM, respectively.
CI-1044 exhibits potent in vivo activity in antigen-induced eosinophil recruitment in rats (ED50=3.2 mg/kg, p.o.).
| M.Wt | 397.438 | |
| Formula | C23H19N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-N-(9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-3-yl)nicotinamide |
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1. Burnouf C, et al. J Med Chem. 2000 Dec 14;43(25):4850-67.
2. Ouagued M, et al. Pulm Pharmacol Ther. 2005;18(1):49-54.
3. Hanton G, et al. Toxicol Lett. 2008 Jun 10;179(1):15-22.
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