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You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-GABA Transporter (GAT)-CI-966 hydrochloride
CI-966 hydrochloride

Chemical Structure : CI-966 hydrochloride

CAS No.: 110283-66-4

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CI-966 hydrochloride (CI966)

Catalog No.: PC-62932Not For Human Use, Lab Use Only.

CI-966 hydrochloride is a potent, selective inhibitor of the GABA transporter GAT-1 with IC50 of 0.26 and 1.2 uM for human and rat GAT-1, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CI-966 hydrochloride is a potent, selective inhibitor of the GABA transporter GAT-1 with IC50 of 0.26 and 1.2 uM for human and rat GAT-1, respectively.
CI-966 displays >200-fold selectivity over GAT-2 and GAT-3.
CI-966 shows anticonvulsive and neuroprotective activity in vivo.

Physicochemical Properties

M.Wt 509.873
Formula C23H22ClF6NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

1-[2-[bis[4-(Trifluoromethyl)phenyl]methoxy]ethyl]-1,2,5,6-tetrahydropyridine-3-carboxylic acid hydrochloride

References

1. Ebert U, et al. Can J Physiol Pharmacol. 1990 Sep;68(9):1194-9.

2. Radulovic LL, et al. Pharm Res. 1993 Oct;10(10):1442-5.

3. Phillis JW. Gen Pharmacol. 1995 Sep;26(5):1061-4.

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