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Chemical Structure : CI-966 hydrochloride
CAS No.: 110283-66-4
Catalog No.: PC-62932Not For Human Use, Lab Use Only.
CI-966 hydrochloride is a potent, selective inhibitor of the GABA transporter GAT-1 with IC50 of 0.26 and 1.2 uM for human and rat GAT-1, respectively.
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|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
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CI-966 hydrochloride is a potent, selective inhibitor of the GABA transporter GAT-1 with IC50 of 0.26 and 1.2 uM for human and rat GAT-1, respectively.
CI-966 displays >200-fold selectivity over GAT-2 and GAT-3.
CI-966 shows anticonvulsive and neuroprotective activity in vivo.
| M.Wt | 509.873 | |
| Formula | C23H22ClF6NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1-[2-[bis[4-(Trifluoromethyl)phenyl]methoxy]ethyl]-1,2,5,6-tetrahydropyridine-3-carboxylic acid hydrochloride |
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1. Ebert U, et al. Can J Physiol Pharmacol. 1990 Sep;68(9):1194-9.
2. Radulovic LL, et al. Pharm Res. 1993 Oct;10(10):1442-5.
3. Phillis JW. Gen Pharmacol. 1995 Sep;26(5):1061-4.
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